ribosomal frameshift การใช้

Recently ( January 2014 ), the first therapeutic compound targeted at the HIV-1 ribosomal frameshift signal was reported by Ofori et al.
The dependence of the HIV-1 virus on this ribosomal frameshift signal has generated interest in the frameshift as a target for novel antiviral therapeutics.
The polyprotein coat of CfMV is made up of two proteins, encoded by overlapping open reading frames ( 2a and 2b ) which are transcribed through a ribosomal frameshift mechanism.
As a result, the HIV-1 ribosomal frameshift signal is highly regulated, as it modulates the expression levels of the Gag protein relative to the Gag-Pol polyprotein.
The HIV-1 virus requires a programmed-1 ribosomal frameshift signal ( the HIV-1 Ribosomal Frameshift Signal ) for the expression of the protease, reverse transcriptase, and integrase ).